Like every high school sophomore, all Andie wants is to have someone like her, date her, and possibly make out with her. When her brother makes it impossible for her to land a date, Andie's three best friends each come up with their own clever way to try and help get Andie out of the sister zone.

Media Club advisor Mr. Shaw threatens to close the club if the Foursome doesn't produce a new episode of the school's newscast, Cup O'Brayer, by end of day. Their plans are derailed when a trip to the school's bake-off leaves the Foursome high as kites.

The foursome is frustrated by all the boy drama in their life and decide they need a girls night + Dakota to forget their problems. But when Josh and Alec's boys night collides with their girls night, they have a showdown to determine who gets to stay, boys or girls.

After a health class condom lesson gone wrong, Andie realizes that she knows nothing about sex, and even if Josh all of the sudden decided he was interested she would be totally unprepared. Dakota and Courtney agree to teach her the bases.

Something is in the air at Brayer High and everyone is hooking up, well everyone but Andie. The Foursome fearing she'll feel left out tries to hide their hook ups from her, but end up abandoning her when she needs them the most.

Courtney invites everyone to a frat party at SUC, but when they wake up the morning after the party and Imogen is missing the Foursome must retrace their steps to find her.